Moderate Intensity Static Magnetic Fields Prevent Thrombus Formation in Rats and Mice.

Autor: Li Q; Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, P.R. China., Liao Z; Zhejiang Heye Health Technology, Anji, P.R. China., Gu L; Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, P.R. China., Zhang L; High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, P.R. China., Zhang L; Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, P.R. China., Tian X; High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, P.R. China., Li J; Zhejiang Heye Health Technology, Anji, P.R. China., Fang Z; Zhejiang Heye Health Technology, Anji, P.R. China., Zhang X; Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, P.R. China.
Jazyk: angličtina
Zdroj: Bioelectromagnetics [Bioelectromagnetics] 2020 Jan; Vol. 41 (1), pp. 52-62. Date of Electronic Publication: 2019 Dec 04.
DOI: 10.1002/bem.22232
Abstrakt: We established three types of thrombosis models to explore the effects of the static magnetic field (SMF) on thrombosis in rats and mice with three different MF intensities. In the carrageenan-induced thrombosis model in rats, the SMF treatments reduced the black tail length of rats, extracorporeal thrombus, and the mass of wet and dry thrombus, and improved the coagulation index value. In FeCl 3 -induced arterial thrombosis model in rats, the SMF treatment showed some anti-thrombotic effects. More specifically, the SMF treatment affected rodent blood pressure, plasma plasminogen activator inhibitor, tissue-type plasminogen activator, thrombus mass, and thrombus protein content. In the adrenaline-induced thrombosis model in mice, the SMF treatment had certain effects on the diameter and blood flow velocity of mouse auricle microcirculation in fine veins and arteries. Overall, the highest MF intensities we tested, 20-150 mT, showed a trend of anti-thrombotic effect, indicating that the moderate-intensity SMF might serve as a potential treatment for clot-related diseases in the future. Bioelectromagnetics. 2020;41:52-62 © 2019 Bioelectromagnetics Society.
(© 2019 Bioelectromagnetics Society.)
Databáze: MEDLINE
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