A case report of exogenous lipoid pneumonia associated with avocado/soybean unsaponifiables.

Autor: Boutros J; Department of Pulmonary Medicine, Université Côte d'Azur, CHU de Nice, FHU OncoAge, 30 avenue de la voie Romaine, CS51069, 06001, Nice, France., Muzzone M; Department of Pulmonary Medicine, Université Côte d'Azur, CHU de Nice, FHU OncoAge, 30 avenue de la voie Romaine, CS51069, 06001, Nice, France., Benzaquen J; Department of Pulmonary Medicine, Université Côte d'Azur, CHU de Nice, FHU OncoAge, 30 avenue de la voie Romaine, CS51069, 06001, Nice, France.; Université Côte d'Azur, CNRS UMR7284, Inserm U1081, Institute of Research on Cancer and Ageing (IRCAN), Nice, France., Levraut M; Department of Pulmonary Medicine, Université Côte d'Azur, CHU de Nice, FHU OncoAge, 30 avenue de la voie Romaine, CS51069, 06001, Nice, France., Marquette CH; Department of Pulmonary Medicine, Université Côte d'Azur, CHU de Nice, FHU OncoAge, 30 avenue de la voie Romaine, CS51069, 06001, Nice, France. marquette.c@chu-nice.fr.; Université Côte d'Azur, CNRS UMR7284, Inserm U1081, Institute of Research on Cancer and Ageing (IRCAN), Nice, France. marquette.c@chu-nice.fr., Rocher F; Université Côte d'Azur, CHU de Nice, Regional Pharmacovigilance Center, Nice, France., Diascorn Y; Department of Radiology, Université Côte d'Azur, CHU de Nice, Nice, France., Padovani B; Department of Radiology, Université Côte d'Azur, CHU de Nice, Nice, France., Hofman V; Laboratory of Clinical and Experimental Pathology, Université Côte d'Azur, CHU de Nice, FHU OncoAge, Nice, France., Leroy S; Department of Pulmonary Medicine, Université Côte d'Azur, CHU de Nice, FHU OncoAge, 30 avenue de la voie Romaine, CS51069, 06001, Nice, France.; Université Côte d'Azur, CNRS UMR 7275 - Institut de Pharmacologie Moléculaire et Cellulaire, Sophia Antipolis, France.
Jazyk: angličtina
Zdroj: BMC pulmonary medicine [BMC Pulm Med] 2019 Dec 03; Vol. 19 (1), pp. 234. Date of Electronic Publication: 2019 Dec 03.
DOI: 10.1186/s12890-019-0997-1
Abstrakt: Background: Exogenous lipoid pneumonia is a rare disease resulting from intra-alveolar accumulation of lipids of mineral, vegetal, or animal origin, that induce a foreign body type of inflammatory reaction in the lungs. Gastroesophageal reflux disease and other esophageal abnormalities have often been associated with this disease.
Case Presentation: We herein report the case of an 83-year-old patient in whom a follow-up chest computed tomography scan, for a lingular consolidation, showed multifocal ground glass and consolidative opacities with areas of low attenuation, suggestive of exogenous lipid pneumonia. The patient had been on piascledine capsules (avocado/soybean unsaponifiables) for 20 years and had a hiatal hernia with documented gastroesophageal reflux disease. After thorough history taking, no other predisposing factors were found. The diagnosis was confirmed using oil red staining of bronchoalveolar lavage showing lipid-laden macrophages and extracellular lipid droplets.
Conclusions: To our knowledge, this is the first case of ELP secondary to avocado/soybean unsaponifiables in the literature.
Databáze: MEDLINE
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