Chronic ingestion of deoxynivalenol-contaminated diet dose-dependently decreases the area of myenteric neurons and gliocytes of rats.

Autor: Rissato DF; Ingá University Center, Maringá, Paraná, Brazil.; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., de Santi Rampazzo AP; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., Borges SC; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., Sousa FC; Coordination of Biological Sciences, Federal University of Technology - Paraná, Dois Vizinhos Campus, Dois Vizinhos, Paraná, Brazil., Busso C; Coordination of Biological Sciences, Federal University of Technology - Paraná, Dois Vizinhos Campus, Dois Vizinhos, Paraná, Brazil., Buttow NC; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., Natali MRM; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.
Jazyk: angličtina
Zdroj: Neurogastroenterology and motility [Neurogastroenterol Motil] 2020 Apr; Vol. 32 (4), pp. e13770. Date of Electronic Publication: 2019 Dec 03.
DOI: 10.1111/nmo.13770
Abstrakt: Background: Deoxynivalenol (DON), a mycotoxin produced by Fusarium spp., is commonly found in cereals ingested by humans and animals. Its ingestion is correlated with hepatic, hematologic, renal, splenic, cardiac, gastrointestinal, and neural damages, according to dose, duration of exposure and species. In this work, the effects of the ingestion of DON-contaminated diet at concentrations considered tolerable for human and animal intake were assessed.
Methods: Male Wistar rats aging 21 days were allotted to five groups that were given, for 42 days, diets contaminated with different concentrations of DON (0, 0.2, 0.75, 1.75, and 2 mg kg -1 of chow). Food ingestion, bodyweight, oxidative status and morphometric analyses of gliocytes, and neurons of jejunal myenteric ganglia were recorded.
Key Results: At these concentrations, there was no food rejection, decrease in bodyweight gain, changes in oxidative status, or loss of either neurons or gliocytes. However, DON decreased gliocyte area, general neuronal population, nitrergic, cholinergic and NADH-diaphorase positive subpopulations and, as a result, ganglion area.
Conclusions & Inferences: It was concluded that, even in the absence of visible effect, DON exposure reduces cell body area of gliocytes and neurons of the myenteric plexus of the rat jejunum.
(© 2019 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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