Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?

Autor: Pieretti JC; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil; Nanomedicine Research Unit (NANOMED), Federal University of ABC (UFABC), Santo André, SP, Brazil., Pelegrino MT; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil; Nanomedicine Research Unit (NANOMED), Federal University of ABC (UFABC), Santo André, SP, Brazil., Nascimento MHM; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil; Nanomedicine Research Unit (NANOMED), Federal University of ABC (UFABC), Santo André, SP, Brazil., Tortella GR; Department of Chemical Engineering, Universidad de La Frontera, Temuco, Chile; Biotechnological Research Center Applied to the Environment (CIBAMA-BIOREN), Universidad de La Frontera, Temuco, Chile., Rubilar O; Department of Chemical Engineering, Universidad de La Frontera, Temuco, Chile; Biotechnological Research Center Applied to the Environment (CIBAMA-BIOREN), Universidad de La Frontera, Temuco, Chile., Seabra AB; Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil; Nanomedicine Research Unit (NANOMED), Federal University of ABC (UFABC), Santo André, SP, Brazil. Electronic address: amedea.seabra@ufabc.edu.br.
Jazyk: angličtina
Zdroj: Biochemical pharmacology [Biochem Pharmacol] 2020 Jun; Vol. 176, pp. 113740. Date of Electronic Publication: 2019 Nov 28.
DOI: 10.1016/j.bcp.2019.113740
Abstrakt: Nitric oxide (NO) is an endogenous free radical that controls important physiological and pathophysiological processes, including a role in cancer biology. NO can have a direct toxic effect on tumors, or it can sensitize cancer cells and contribute to the reversal of multidrug resistance (MDR). As NO is a gas and free radical, NO donors have been investigated for their anticancer effects. In recent years, the combination of NO donors with nanomaterials has been emerging as a promising strategy to promote spatial-temporal NO release/generation directly at the target site of application (tumor tissue). Smart nanocarriers that are able to release NO under controlled stimuli have been extensively developed. Moreover, important publications have demonstrated the promising applications of NO-releasing nanomaterials in combination with traditional chemotherapies in which NO can sensitize cancer cells. In this direction, this review presents and discusses the recent progress in the design of versatile nanocarriers that are able to release/generate therapeutic amounts of NO and which can be combined with conventional anticancer therapies. These nanocarriers have the ability to release NO on-demand by external stimuli such as pH, wave, or light exposure. In addition, the possible mechanisms of NO in sensitizing tumor tissue and the impact and challenges of nanomaterials in cancer treatment are also presented and discussed. The biological and pharmacological aspects of NO donors in cancer are discussed. Finally, challenges and perspectives in the development of versatile nanoplatforms to efficiently deliver NO in clinical cancer treatment are highlighted.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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