Activity in Lateral Visual Areas Contributes to Surround Suppression in Awake Mouse V1.

Autor:	Vangeneugden J; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., van Beest EH; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Cohen MX; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Lorteije JAM; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Mukherjee S; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Kirchberger L; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Montijn JS; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Thamizharasu P; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Camillo D; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Levelt CN; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands., Roelfsema PR; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands; Psychiatry Department, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Electronic address: p.roelfsema@nin.knaw.nl., Self MW; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands. Electronic address: m.self@nin.knaw.nl., Heimel JA; Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands. Electronic address: heimel@nin.knaw.nl.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2019 Dec 16; Vol. 29 (24), pp. 4268-4275.e7. Date of Electronic Publication: 2019 Nov 27.
DOI:	10.1016/j.cub.2019.10.037
Abstrakt:	Neuronal response to sensory stimuli depends on the context. The response in primary visual cortex (V1), for instance, is reduced when a stimulus is surrounded by a similar stimulus [1-3]. The source of this surround suppression is partially known. In mouse, local horizontal integration by somatostatin-expressing interneurons contributes to surround suppression [4]. In primates, however, surround suppression arises too quickly to come from local horizontal integration alone, and myelinated axons from higher visual areas, where cells have larger receptive fields, are thought to provide additional surround suppression [5, 6]. Silencing higher visual areas indeed decreased surround suppression in the awake primate by increasing responses to large stimuli [7, 8], although not under anesthesia [9, 10]. In smaller mammals, like mice, fast surround suppression could be possible without feedback. Recent studies revealed a small reduction in V1 responses when silencing higher areas [11, 12] but have not investigated surround suppression. To determine whether higher visual areas contribute to V1 surround suppression, even when this is not necessary for fast processing, we inhibited the areas lateral to V1, particularly the lateromedial area (LM), a possible homolog of primate V2 [13], while recording in V1 of awake and anesthetized mice. We found that part of the surround suppression depends on activity from lateral visual areas in the awake, but not anesthetized, mouse. Inhibiting the lateral visual areas specifically increased responses in V1 to large stimuli. We present a model explaining how excitatory feedback to V1 can have these suppressive effects for large stimuli. (Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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