HepCare Europe-A service innovation project. HepCheck: Characteristics of the patient population with active infection as defined by HCV RNA.

Autor:	Avramovic G; Mater Misericordiae University Hospital, Ireland; University College Dublin, Ireland., Oprea C; Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Romania., Surey J; University College London, UK., Story A; University College London Hospital, UK., Macías J; Hospital Universitario de Valme, Spain., Cullen W; University College Dublin, Ireland., Iglesias M; Hospital Universitario de Valme, Spain., Mc Hugh T; Mater Misericordiae University Hospital, Ireland., Crowley D; Health Service Executive, Ireland., Naughton AM; Health Service Executive, Ireland., Horan A; Health Service Executive, Ireland., Ianache I; Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Romania., Lazar S; Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Romania., Popa I; Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Romania., Menezes D; University College London, UK., Lambert JS; Mater Misericordiae University Hospital, Ireland; University College Dublin, Ireland. Electronic address: jlambert@mater.ie.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2020 Feb; Vol. 91, pp. 246-251. Date of Electronic Publication: 2019 Nov 27.
DOI:	10.1016/j.ijid.2019.11.027
Abstrakt:	Background: Hepatitis C virus (HCV) is a main cause of chronic liver disease worldwide and is consistently under-diagnosed. Community-based screening initiatives, such as HepCheck, have been identified as important components of HCV care. HepCheck focuses on screening and identifying HCV RNA-positive cases in high-risk populations and linking them to care as part of a larger European project to improve HCV care (HepCare). Methods: HCV testing with a self-administered questionnaire was offered to 2822 individuals. Results: There were 2079 patients screened. Overall, 397 (19%) of the total screened cohort were identified as having active HCV infections as measured by HCV RNA PCR. The patients were mostly male (84%), white (88%), and had a history of injecting drug use (IDU) (86%), homelessness (58%), and tattooing (42%). There were 136 new cases (7% of the total sample and 34% of identified active infections). Romania had the highest proportion of newly identified cases with 87%, then Ireland with 60%, and Spain with 43%; the UK had the lowest proportion of new cases at 10%. Conclusions: For those lost to follow-up, a major strategy is re-engagement. For those newly diagnosed, the 'seek and treat' approach is a key strategy. Thus, different priorities are defined for different countries. (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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