The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood.

Autor: Savonius O; Children's Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland., Roine I; Faculty of Medicine, University Diego Portales, Santiago, Chile., Alassiri S; Department of Oral and Maxillofacial Diseases, Institute of Dentistry, Helsinki University Hospital and the University of Helsinki, Helsinki, Finland., Tervahartiala T; Department of Oral and Maxillofacial Diseases, Institute of Dentistry, Helsinki University Hospital and the University of Helsinki, Helsinki, Finland., Helve O; Children's Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland., Fernández J; Clínica Infantil Dr. Robert Reid Cabral, Santo Domingo, Dominican Republic., Peltola H; Children's Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland., Sorsa T; Department of Oral and Maxillofacial Diseases, Institute of Dentistry, Helsinki University Hospital and the University of Helsinki, Helsinki, Finland.; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden., Pelkonen T; Children's Hospital, Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Mediators of inflammation [Mediators Inflamm] 2019 Nov 03; Vol. 2019, pp. 7436932. Date of Electronic Publication: 2019 Nov 03 (Print Publication: 2019).
DOI: 10.1155/2019/7436932
Abstrakt: Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes.
Methods: Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996-2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays.
Results: MPO correlated positively with MMP-8 (rho 0.496, P < 0.001) and MMP-9 (rho 0.153, P = 0.02) but negatively with TIMP-1 (rho -0.361, P < 0.001). MMP-8 emerged as the best predictor of disease outcomes: a CSF MMP-8 concentration above the median increased the odds of death 4.9-fold (95% confidence interval 1.8-12.9).
Conclusions: CSF MMP-8 presented as an attractive prognostic marker in children with bacterial meningitis.
Competing Interests: Prof. Timo Sorsa is an inventor of US patents 5652223, 5736341, 5866432, and 6143476. All the other authors report no conflict of interest.
(Copyright © 2019 Okko Savonius et al.)
Databáze: MEDLINE
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