Predictive risk factors for autoimmune thyroid diseases in patients with pernicious anemia.

Autor:	Souto Filho JTD; Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil; Instituto Federal de Educação, Ciência e Tecnologia Fluminense, Campos dos Goytacazes, Rio de Janeiro, Brazil. Electronic address: drjoaotadeu@yahoo.com.br., Beiral ES; Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil., Azevedo FS; Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil., Gonçalves JGRRS; Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil., Kohler LIA; Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil., Guimarães SS; Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil.
Jazyk:	English; Spanish; Castilian
Zdroj:	Medicina clinica [Med Clin (Barc)] 2020 May 08; Vol. 154 (9), pp. 344-347. Date of Electronic Publication: 2019 Nov 25.
DOI:	10.1016/j.medcli.2019.09.022
Abstrakt:	Background: Patients with pernicious anemia (PA) have a higher prevalence of other autoimmune diseases. We assessed the correlation between PA and autoimmune thyroid diseases (AITD), and evaluated the risk factors for this association. Methods: A longitudinal study was conducted involving patients with PA between 2010 and 2017. Results: A total of 86 patients with PA were evaluated, 74 (86%) female, with a median age of 51.5 years. Thyroid abnormalities were detected in 45 (52.3%) patients, including 28 (32.3%) hypothyroidism, 3 (3.5%) hyperthyroidism and 20 (23.3%) thyroperoxidase antibody positivity. Logistic regression analysis identified risk factors for having AITD in PA patients: weight loss (OR 12.03; 95% CI 1.06-137.02, P=0.045), diabetes mellitus (OR 4.68, 95% CI 1.15-26.58, P=0.047) and gastric antibodies positivity (OR 5.05, 95% CI 1.45-18.24, P=0.013). Conclusion: PA and AITD are frequently associated, suggesting all patients with PA should be investigated for occult thyroid disease, especially those with weight loss, diabetes mellitus and gastric autoantibodies. (Copyright © 2019 Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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