Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus.

Autor:	Oliveira TSS; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Reabilitação, Salvador, BA, Brasil.; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Imunologia, Salvador, BA, Brasil., Andrade RCP; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Reabilitação, Salvador, BA, Brasil.; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Imunologia, Salvador, BA, Brasil., Santos DND; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Reabilitação, Salvador, BA, Brasil., Orrico KF; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Imunologia, Salvador, BA, Brasil., Abraão Neto J; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Imunologia, Salvador, BA, Brasil., Oliveira CJV; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Imunologia, Salvador, BA, Brasil., Rocha PN; Universidade Federal da Bahia, Escola de Medicina, Departamento de Medicina Interna e Apoio Diagnóstico, Salvador, BA, Brasil., Carvalho EM; Universidade Federal da Bahia, Complexo Hospitalar Professor Edgard Santos, Departamento de Imunologia, Salvador, BA, Brasil.; Fundação Oswaldo Cruz-Bahia, Instituto Gonçalo Moniz, Laboratório de Pesquisas Clínicas, Salvador, BA, Brasil.; Ministério da Ciência, Tecnologia, Inovações e Comunicações, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Salvador, BA, Brasil.
Jazyk:	angličtina
Zdroj:	Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2019 Nov 14; Vol. 52, pp. e20180486. Date of Electronic Publication: 2019 Nov 14 (Print Publication: 2019).
DOI:	10.1590/0037-8682-0486-2018
Abstrakt:	Introduction: Bowel dysfunction is frequent in patients with spinal cord diseases, but little is known about the prevalence of bowel symptoms in human T-lymphotropic virus-(HTLV-1) infected individuals. The purpose of this study is to determine the frequency of bowel symptoms in HTLV-1 infected individuals and their correlation with the degree of neurologic disease. Methods: This is a cross-sectional study comparing the frequency of bowel symptoms in HTLV-1-infected individuals* and seronegative donors (controls). Patients answered a questionnaire, the Rome III Criteria was applied, and stool consistency was evaluated by the Bristol Stool Form Scale. The individuals were classified as HTLV-1 carriers, probable HTLV-1 myelopathy and definitive HTLV-1 associated myelopathy or tropical spastic paraparesis (definitive HAM / TSP)**. Results: We studied 72 HTLV-1 infected individuals and 72 controls with equal age and gender distribution. Constipation was the most frequent complaint, occurring in 38 % of HTLV-1 individuals and in 15 % of the controls. In comparison to the seronegative controls, the probability of constipation occurrence was approximately 18 times higher in definitive HAM / TSP patients. Straining, lumpy or hard stools, sensation of anorectal obstruction/blockage, fewer than 3 defecations per week, flatulence, soiling, evacuation pain, and bleeding were also more frequent in the HTLV-1 patients than in the controls. Moreover, bowel symptoms were more frequent in patients with definitive or probable HAM / TSP than in carriers. Conclusions: Bowel symptoms were more frequent in HTLV-1-infected patients than in seronegative controls and the frequency of bowel symptoms correlated with the severity of neurologic disease.
Databáze:	MEDLINE
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