| Autor: |
Fleischman LF; Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111., Cantley L |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of physiology [Am J Physiol] 1988 Oct; Vol. 255 (4 Pt 1), pp. C531-5. |
| DOI: |
10.1152/ajpcell.1988.255.4.C531 |
| Abstrakt: |
To investigate the timing of inositol lipid turnover in relation to the cell cycle, inositol phosphates and lipids were measured in neuroblastoma (Neuro-2A) cells that were prelabeled with [3H]inositol and synchronized by a mitotic shakeoff technique. Distinct early and late phases of inositol phosphate production were identified. The early peak occurs between the 2nd and 4th hour after mitosis near the G1/S transition. A later peak occurs around the peak of S phase (DNA synthesis) at 7-8 h after mitosis. These findings suggest that activation of phosphatidylinositol turnover generates signals that play a role in cell cycle progression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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