Protein Carbonyl Content Is a Predictive Biomarker of Eccentric Left Ventricular Hypertrophy in Hemodialysis Patients.

Autor: Dimitrijevic ZM; Faculty of Medicine, University of Nis, 18000 Nis, Serbia.; Clinical Center Nis, Clinic for Nephrology, 18000 Nis, Serbia., Salinger Martinovic SS; Faculty of Medicine, University of Nis, 18000 Nis, Serbia.; Clinical Center Nis, Clinic for Cardiovascular Disease, 18000 Nis, Serbia., Nikolic VN; Faculty of Medicine, University of Nis, 18000 Nis, Serbia.; Pharmacology Department, Faculty of Medicine, University of Nis, 18000 Nis, Serbia., Cvetkovic TP; Faculty of Medicine, University of Nis, 18000 Nis, Serbia.; Clinical Center Nis, Center for Medical Biochemistry, 18000 Nis, Serbia.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2019 Nov 25; Vol. 9 (4). Date of Electronic Publication: 2019 Nov 25.
DOI: 10.3390/diagnostics9040202
Abstrakt: High prevalence of left ventricular hypertrophy (LVH) and elevated oxidative stress are associated with poor outcomes in chronic hemodialysis patients. Abnormal left ventriculаr geomеtry and different geometric patterns play an important role as well. Our study analyzed the role of oxidative stress on myocardial remodeling in these patients. Plasma malondialdehyde (MDA), protein carbonyl (PC) content, and total antioxidative capacity (TAC) were investigated in 104 hemodialysis patients together with transthoracic echocardiography. Compared to patients with normal ventricular geometry, patients with LVH had increased MDA and PC plasma concentration. Multivariate analysis demonstrated that protein carbonyls, as biomarkers of oxidative protein modification, were an independent predictor of eccentric hypertrophy (eLVH), including higher LV end-diastolic diameter and LV end-diastolic volume, (β = 0.32 and β = 0.28, p < 0.001 for both). The incidence of eLVH increased progressively from the lowest to the highest baseline PC tertile ( p < 0.001 for the trend) and the subjects in the former group showed a 76% greater risk of developing eLVH compared to their counterparts. After further adjustment for the potential mediators, PCs carried eLVH odds (95% confidence interval (CI)) of 1.256 (0.998-1.514), per standard deviation increase. High plasma protein carbonyls levels are a significant independent predictor of eccentric LVH in chronic hemodialysis patients.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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