Bioaccumulation and Distribution Behavior of Endosulfan on a Cichlid Fish: Differences Between Exposure to the Active Ingredient and a Commercial Formulation.

Autor: Da Cuña RH; Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Laboratorio de Ecotoxicología Acuática, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.; Instituto de Biodiversidad y Biología Experimental, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Argentina., Lo Nostro FL; Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Laboratorio de Ecotoxicología Acuática, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.; Instituto de Biodiversidad y Biología Experimental, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, Argentina., Shimabukuro V; Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones Marinas y Costeras, Laboratorio de Ecotoxicología y Contaminación Ambiental, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, Mar del Plata, Buenos Aires, Argentina., Ondarza PM; Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones Marinas y Costeras, Laboratorio de Ecotoxicología y Contaminación Ambiental, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, Mar del Plata, Buenos Aires, Argentina., Miglioranza KSB; Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones Marinas y Costeras, Laboratorio de Ecotoxicología y Contaminación Ambiental, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, Mar del Plata, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Environmental toxicology and chemistry [Environ Toxicol Chem] 2020 Mar; Vol. 39 (3), pp. 604-611. Date of Electronic Publication: 2020 Jan 28.
DOI: 10.1002/etc.4643
Abstrakt: Persistent organic pollutants reach aquatic ecosystems during application and can bioconcentrate/biomagnify because of their lipophilic nature. Toxicological studies focus almost exclusively on the active ingredients of pesticides, instead of commercial formulations, whose toxicity can differ as a result of nonspecified ingredients. The intensive use of endosulfan as a wide-ranging insecticide over the last few decades makes it one of the most frequently detected contaminants in the aquatic environment, even after it has been restricted worldwide. The aim of the present study was to evaluate the bioaccumulation and organ distribution of waterborne endosulfan in the freshwater fish Cichlasoma dimerus, comparing the active ingredient and a commercial formulation. Males were exposed to 0.7 μg/L endosulfan for 2 wk, which was quantified (gas chromatography with an electron capture detector) in the liver, testes, gills, brain, and muscle. The results suggest rapid metabolism of α-endosulfan and β-endosulfan isomers to endosulfan sulfate (endosulfan-S) in tissues. Isomer levels were highest in gills, indicative of recent uptake. Levels of endosulfan-S were highest in liver and testes for the active ingredient and testes and brain for the commercial formulation. For the active ingredient, endosulfan-S levels showed a positive correlation with organ-lipid percentage. No correlation was evident for the commercial formulation, indicating that the presence of adjuvants alters endosulfan distribution because gills and liver showed a higher uptake and mobilization of β-endosulfan. These differences in organ distribution may alter tissue-specific toxicity; therefore, additives cannot be considered inactive even if nontoxic. Environ Toxicol Chem 2020;39:604-611. © 2019 SETAC.
(© 2020 SETAC.)
Databáze: MEDLINE
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