Vanadyl sulphate ameliorates biomarkers of endothelial injury and coagulation and thrombosis in a rat model of hyperglycaemia.

Autor: Haidara MA; Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.; Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt., Al-Ani B; Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia., Bin-Jaliah I; Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia., Shams Eldeen AM; Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo, Egypt., Morsy MD; Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.; Department of Physiology, College of Medicine, Menoufia University, Shibin el Kom, Egypt.
Jazyk: angličtina
Zdroj: Archives of physiology and biochemistry [Arch Physiol Biochem] 2022 Apr; Vol. 128 (2), pp. 447-454. Date of Electronic Publication: 2019 Nov 27.
DOI: 10.1080/13813455.2019.1691602
Abstrakt: Background: We sought to determine whether the insulin mimicking agent, vanadyl sulphate (Van) can inhibit biomarkers of endothelial injury and coagulation and thrombosis induced by a moderate level of hyperglycaemia.
Material and Methods: Hyperglycaemia was induced in rats by a single injection of streptozotocin (STZ, 50 mg/kg) two weeks after being fed on a high-fat diet (model group). The treatment group started Van (20 mg/kg/day) treatment one-week post STZ injection and continued on Van until being sacrificed at week 10.
Results: Administration of Van to the model group significantly ( p  < .05) ameliorated dyslipidemia and biomarkers of inflammation (TNF-α, IL-6, and hsCRP) and endothelial injury (E-selectin, P-selectin, sICAM-1, sVCAM-1, and ET-1). Van also significantly inhibited hyperglycaemia-induced blood levels of coagulation (vWF) and thrombosis (PAI-1 and fibrinogen) biomarkers.
Conclusions: Vanadyl sulphate effectively suppresses hyperglycaemia-induced endothelial injury, coagulation and thrombosis, which is associated with the inhibition of inflammation and dyslipidemia.
Databáze: MEDLINE
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