| Autor: |
Viet Cuong LC; Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam., Anh LT; Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam.; Graduate University of Science and Technology, VAST, Hanoi City, Vietnam., Huu Dat TT; Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam., Anh TTP; Graduate University of Science and Technology, VAST, Hanoi City, Vietnam., Lien LQ; Department of International Co-Operation, VAST, Hanoi City, Vietnam., Kim YH; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea., Tuan Anh HL; Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam.; Graduate University of Science and Technology, VAST, Hanoi City, Vietnam. |
| Abstrakt: |
A new ursane-type triterpene, 3 β ,23,24-trihydroxyurs-12-en-28-oic acid ( 1 ), together with eight known compounds ( 2 - 9 ) were isolated from the aerial parts of Ophiorrhiza baviensis . Among them, compounds 2 - 5 were found for the first time from the genus Ophiorrhiza , while compounds 6 - 9 were reported from O. baviensis for the first time. Their structures were elucidated by analysis of HR-ESI-MS and NMR ( 1 H-NMR, 13 C-NMR, HSQC, and HMBC) spectra, as well as comparison with those reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against MCF-7, Hela, KB, A549, and SK-LU-1 cancer cell lines and their effects on LPS-induced NO production in RAW264.7 cells. This is the first report of chemical constituents and biological activities of O. baviensis . |
