Sitagliptin protects male albino rats with testicular ischaemia/reperfusion damage: Modulation of VCAM-1 and VEGF-A.

Autor: Abdel-Aziz AM; Departments of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt., Naguib Abdel Hafez SM; Departments of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, Egypt.
Jazyk: angličtina
Zdroj: Andrologia [Andrologia] 2020 Mar; Vol. 52 (2), pp. e13472. Date of Electronic Publication: 2019 Nov 26.
DOI: 10.1111/and.13472
Abstrakt: Twisting of the spermatic cord is considered a popular problem in the urological field, which may lead to testicular necrosis and male infertility. Sitagliptin, a glucose-lowering agent, proved to have a vindicatory function in myocardial and renal ischaemia/reperfusion (I/R), but its role in testicular I/R has not yet been studied. The current work investigates its capability to recover the testicular I/R injury with shedding more light on the mechanism of its action. Four groups were used: sham, sham pretreated with sitagliptin, I/R and sitagliptin/I/R-pretreated groups. The outcomes proved that I/R significantly decreased the serum testosterone, with a major increase in oxidative, inflammatory and nitrosative stress, along with a reduction in testicular vascular endothelial growth factor-A level with marked germinal cell apoptosis. However, pretreatment with sitagliptin significantly reversed the profound testicular I/R damaging effects, on the basis of its antioxidant, anti-inflammatory and anti-apoptotic activities with the ability of recuperation of the testicular vascularity.
(© 2019 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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