Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain).

Autor: Ruiz de Sabando A; Department of Medical Genetics, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain.; Navarrabiomed, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Urrutia Lafuente E; Department of Medical Genetics, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain.; Navarrabiomed, Pamplona, Spain., García-Amigot F; Department of Medical Genetics, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Alonso Sánchez A; Department of Medical Genetics, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain.; Navarrabiomed, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Morales Garofalo L; Department of Medical Genetics, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain., Moreno S; Department of Medical Genetics, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain., Ardanaz E; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.; Navarra Public Health Institute, Pamplona, Spain.; CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain., Ramos-Arroyo MA; Department of Medical Genetics, Complejo Hospitalario de Navarra (CHN), Pamplona, Spain. ma.ramos.arroyo@navarra.es.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. ma.ramos.arroyo@navarra.es.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2019 Nov 27; Vol. 19 (1), pp. 1145. Date of Electronic Publication: 2019 Nov 27.
DOI: 10.1186/s12885-019-6277-x
Abstrakt: Background: Genetic testing for BRCA1/2 genes is widely used as a strategy to reduce incidence and morbidity of hereditary breast and ovarian cancer (HBOC). The purpose of this study is to analyse the demographic and molecular characteristics of BRCA germline mutations in Navarra, Spain, and to investigate the clinical profile of hereditary and sporadic breast cancer (BC) and ovarian cancer (OC) in the Community.
Methods: The study includes 1246 individuals assessed for BRCA1/2 genetic testing in Navarra, during 2000-2016, and a cohort of BC (n = 4384) and OC (n = 561) from the population-based Navarra Cancer Registry. Distribution and molecular characteristics of BRCA1/2 mutations, as well as, comparative analysis of the clinical course, pathologic features and overall survival (OS) of patients in different risk groups were investigated.
Results: BRCA mutation detection rate was 16%, with higher proportion (63%) of BRCA2 families. Nineteen per cent of mutations were recurrent, one of which, BRCA2 c.6024dupG, showed high association to OC. BRCA carriers had double risk (95% CI = 1.04-4.33) of developing multiple malignancies than low risk families and were diagnosed at a much earlier age (16.6 and 11.7 years difference for BC and OC, respectively) when compared to the general population. For BC, BRCA carriers showed a more advanced histological stage, higher risk of bilateral neoplasms (OR = 4.3; 95% CI = 1.3-11.4, for BRCA2 carriers) and worse OS rate at 5-, 10- and 15- years, than women with sporadic tumors. For OC, over 70% of patients of all risk groups showed advanced stages at diagnosis, with the highest among BRCA1 carriers (91%). Furthermore, they also had higher probability of developing ovarian bilateral tumors (OR = 7.8, 95% CI = 1.7-55.7, for BRCA1 carriers) than the general population. Five-year OS rate was worse among women with sporadic OC than BRCA carriers, but it levelled out over the 15-year period.
Conclusions: In addition to national similarities in the HBOC-BRCA1/2 associated mutational spectrum, we identified a recurrent BRCA2 pathogenic variant (c.6024dupG), highly associated to OC in Navarra. Carriers of BRCA1/2 mutations showed a more severe BC and OC phenotype and had a worse overall prognosis when compared to a large cohort of women with sporadic counterpart tumors.
Databáze: MEDLINE
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