| Autor: |
Keirns BH, Anderson KL, Ojo BA, Washburn KF, El-Rassi GD, Lightfoot SA; Department of Pathology , University of Oklahoma Health Sciences Center , Oklahoma City , Oklahoma 73104 , United States., Carver BF, Lucas EA, Smith BJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of agricultural and food chemistry [J Agric Food Chem] 2019 Dec 26; Vol. 67 (51), pp. 14027-14037. Date of Electronic Publication: 2019 Dec 16. |
| DOI: |
10.1021/acs.jafc.9b05851 |
| Abstrakt: |
Wheat consumption has declined amid growing concerns about gluten-sensitivity. To determine if genetic manipulation of wheat contributes to systemic and localized gut inflammation, we compared the effects of the modern variety Gallagher and a blend of two heirloom varieties, Turkey and Kharkof, on measures of gut inflammation, structural characteristics, and barrier integrity under normal and Western diet (WD) conditions in C57BL/6 mice. Indicators of gut inflammation, including lymphocyte infiltration and cytokine expression, were largely unaffected by WD or wheat, although WD elevated interferon-γ ( Ifng ) and heirloom varieties modestly reduced interleukin-17 ( Il17 ) in the context of WD. WD negatively affected jejunal villi structure, while the modern variety improved villi structure in the ileum. Relative mRNA and tight junction proteins and serum lipopolysaccharide binding protein were unaltered by WD or wheat. These findings indicate that the modern variety did not compromise barrier function or contribute to gut inflammation compared to its heirloom predecessor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
