Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application.

Autor: Pantelić I; Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11 221 Belgrade, Serbia. Electronic address: ivana.pantelic@pharmacy.bg.ac.rs., Lukić M; Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11 221 Belgrade, Serbia. Electronic address: milica.lukic@pharmacy.bg.ac.rs., Gojgić-Cvijović G; Department of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, 11 000 Belgrade, Serbia. Electronic address: ggojgic@chem.bg.ac.rs., Jakovljević D; Department of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, 11 000 Belgrade, Serbia. Electronic address: djakovlj@chem.bg.ac.rs., Nikolić I; Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11 221 Belgrade, Serbia. Electronic address: ines.nikolic@pharmacy.bg.ac.rs., Lunter DJ; Institut für Pharmazeutische Technologie, Eberhard-Karls Universität, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. Electronic address: dominique.lunter@uni-tuebingen.de., Daniels R; Institut für Pharmazeutische Technologie, Eberhard-Karls Universität, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. Electronic address: rolf.daniels@uni-tuebingen.de., Savić S; Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11 221 Belgrade, Serbia. Electronic address: snezana.savic@pharmacy.bg.ac.rs.
Jazyk: angličtina
Zdroj: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2020 Jan 15; Vol. 142, pp. 105109. Date of Electronic Publication: 2019 Nov 23.
DOI: 10.1016/j.ejps.2019.105109
Abstrakt: Ongoing demand in sustainable and biocompatible drug dosage forms is reflected in the search for novel pharmaceutical excipients with equal properties. A group of microbial exopolysaccharides offers a variety of biopolymers with many alleged uses and effects. This study aims to assess applicative properties of levan obtained from Bacillus licheniformis NS032, focusing on its potential co-stabilizing and drug release-controlling functions in pertaining emulsion systems. Despite its high molecular weight and partial existence in globular nanometric structures (180-190 nm), levan was successfully incorporated into both tested colloidal systems: those stabilized with synthetic/anionic or natural-origin/non-ionic emulsifiers. In the tested levan concentrations range (0.2-3.0% w/w) the monitored flow and thermal parameters failed to show linear concentration dependence, which prompted us to revisit certain colloidal fundamentals of this biopolymer. Being a part of the external phase of the investigated emulsion systems, levan contributed to formation of a matrix-like environment, offering additional stabilization of the microstructure and rheology modifying properties (hysteresis loop elevation as high as 4167±98 to 20792±3166 Pa•s -1 ), especially in case of the samples where lamellar liquid crystalline formation occurred. Apart from its good water solubility and considerable conformational flexibility, the investigated homofructan easily saturated the external phase of the samples stabilized with a conventional anionic emulsifier, leading to similar properties of 0.2% and 3.0% levan-containing samples. After closer consideration of thermal and release behavior, this was considered as a favorable property for a novel excipient, offering tailored formulation characteristics even with lower levan concentrations, consequently not compromising the potential cost of the final drug dosage form.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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