Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D.

Autor: Ismail AM; Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Zhou X; Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Dyer DW; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, OK, USA., Seto D; Bioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, VA, USA., Rajaiya J; Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Chodosh J; Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2019 Dec; Vol. 593 (24), pp. 3583-3608. Date of Electronic Publication: 2019 Dec 11.
DOI: 10.1002/1873-3468.13693
Abstrakt: Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.
(© 2019 Federation of European Biochemical Societies.)
Databáze: MEDLINE
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