| Autor: |
Topchieva LV; Institute of Biology, Federal Research Center Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia. topchieva67@mail.ru., Balan OV; Institute of Biology, Federal Research Center Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia., Korneeva VA; Petrozavodsk State University, Petrozavodsk, Russia., Malysheva IE; Institute of Biology, Federal Research Center Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Nov; Vol. 168 (1), pp. 79-83. Date of Electronic Publication: 2019 Nov 25. |
| DOI: |
10.1007/s10517-019-04652-4 |
| Abstrakt: |
The risk of essential arterial hypertension was assessed in carriers of the NOS2 gene variants (rs1800482 (-954G>C), rs3730017 (C>T)). In subjects carrying C allele (rs1800482), the risk for essential arterial hypertension developing was higher by 1.7 times (OR=1.712, 95%CI 1.07-2.74), while the presence of T-allele (rs3730017) had a protective effect (OR=0.304, 95%CI 0.192-0.482). In patients with essential arterial hypertension, the presence of the C allele (rs1800482) was associated with a higher content of NO metabolites in the blood plasma. A positive correlation was found between the plasma content of nitrites and nitrates and the level of transcripts of VCAM1, ICAM1 genes in peripheral blood leukocytes. We found the influence of the C allele carriership on the expression VCAM1 and ICAM1 genes in patients with essential hypertension. It was hypothesized that this polymorphic site in the NOS2 gene can be involved in the development of endothelial dysfunction and essential arterial hypertension through modulation of NO level under condition of inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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