| Autor: |
Korovaitseva GI; Research Сenter of Mental Health, Moscow, Russia. korovaitseva@mail.ru., Gabaeva MV; Research Сenter of Mental Health, Moscow, Russia., Yunilainen OA; Research Сenter of Mental Health, Moscow, Russia., Golimbet VE; Research Сenter of Mental Health, Moscow, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Nov; Vol. 168 (1), pp. 84-86. Date of Electronic Publication: 2019 Nov 25. |
| DOI: |
10.1007/s10517-019-04653-3 |
| Abstrakt: |
The role of the VNTR polymorphism of the AS3MT gene in determining the clinical features of schizophrenia and schizophrenic spectrum disorders was studied. The analysis included 670 individuals. We found no differences in PANSS scores for positive, negative, and common psychopathological symptoms between the carriers of different genotypes. The interaction of the studied polymorphism and obstetrical complications as an environmental factor was found. The genotype-environment interactions were identified for one of the characteristics reflecting the severity of schizophrenia: the level of negative symptoms. Women with the V2/V2 genotype, who have obstetrical complications, showed significantly higher negative symptoms scores, which was associated with a poor prognosis of the disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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