Genetic diversity and geographical distribution of the Siberian subtype of the tick-borne encephalitis virus.

Autor: Tkachev SE; Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Acad. Lavrentyev's pr., 8, Novosibirsk, 630090, Russia. Electronic address: tkachev@niboch.nsc.ru., Babkin IV; Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Acad. Lavrentyev's pr., 8, Novosibirsk, 630090, Russia., Chicherina GS; Institute of Systematics and Ecology of Animals SB RAS, Frunze str., 11, Novosibirsk, 630091, Russia., Kozlova IV; Scientific Centre for Family Health and Human Reproduction Problems, Timiryazev Str., 16, Irkutsk, 664003, Russia., Verkhozina MM; Center for Hygiene and Epidemiology in the Irkutsk Region, Trilisser Str., 51, Irkutsk, 664047, Russia., Demina TV; Irkutsk State Agrarian University by A.A. Ezhevsky, Molodezhny Settlement, Irkutsk District, Irkutsk, 664038, Russia., Lisak OV; Scientific Centre for Family Health and Human Reproduction Problems, Timiryazev Str., 16, Irkutsk, 664003, Russia., Doroshchenko EK; Scientific Centre for Family Health and Human Reproduction Problems, Timiryazev Str., 16, Irkutsk, 664003, Russia., Dzhioev YP; Research Institute of Biomedical Technology of Irkutsk State Medical University, Krasnogo Vosstaniya Str., 1/3, Irkutsk, 664003, Russia., Suntsova OV; Scientific Centre for Family Health and Human Reproduction Problems, Timiryazev Str., 16, Irkutsk, 664003, Russia., Belokopytova PS; Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Acad. Lavrentyev's pr., 8, Novosibirsk, 630090, Russia., Tikunov AY; Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Acad. Lavrentyev's pr., 8, Novosibirsk, 630090, Russia., Savinova YS; Scientific Centre for Family Health and Human Reproduction Problems, Timiryazev Str., 16, Irkutsk, 664003, Russia., Paramonov AI; Scientific Centre for Family Health and Human Reproduction Problems, Timiryazev Str., 16, Irkutsk, 664003, Russia., Glupov VV; Institute of Systematics and Ecology of Animals SB RAS, Frunze str., 11, Novosibirsk, 630091, Russia., Zlobin VI; Research Institute of Biomedical Technology of Irkutsk State Medical University, Krasnogo Vosstaniya Str., 1/3, Irkutsk, 664003, Russia., Tikunova NV; Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Acad. Lavrentyev's pr., 8, Novosibirsk, 630090, Russia. Electronic address: tikunova@niboch.nsc.ru.
Jazyk: angličtina
Zdroj: Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2020 Mar; Vol. 11 (2), pp. 101327. Date of Electronic Publication: 2019 Nov 07.
DOI: 10.1016/j.ttbdis.2019.101327
Abstrakt: The tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, is currently subdivided into three main subtypes-the European (TBEV-Eu), the Far-Eastern (TBEV-FE), and the Siberian (TBEV-Sib). The TBEV-Sib is the most common subtype and found in all regions where TBEV was detected, except for Central and Western Europe. Currently, four genetic lineages have been described within TBEV-Sib. In this study, detailed analysis of TBEV-Sib genetic diversity, geographic distribution, phylogeography and divergence time of different TBEV-Sib genetic lineages based on E gene fragments, complete genome sequences, and all currently available data in the GenBank database was performed. As a result, a novel Bosnia lineage within the TBEV-Sib was identified. It was demonstrated that the Zausaev lineage is the most widely distributed among the TBEV-Sib lineages, and was detected in all studied regions except the Far East. The Vasilchenko lineage was found from Western Siberia to the Far East. The Baltic lineage is presented from Europe to Western Siberia. The Obskaya lineage was found only in Western Siberia. TBEV strains from a newly described Bosnia lineage were detected in Bosnia, the Crimean peninsula, Kyrgyzstan and Kazakhstan. The greatest divergence of the TBEV-Sib genetic variants was observed in Western Siberia. Within the TBEV-Sib, the Obskaya lineage diverged from the common ancestor the earliest, after that the Bosnia lineage was separated, then the Baltic lineage, and the Zausaev and Vasilchenko lineages diverged most recently.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2019 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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