Preclinical cardiac disease in nonalcoholic fatty liver disease with and without metabolic syndrome.

Autor:	Makker J; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA., Tariq H; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA., Bella JN; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Cardiology Bronx, NY 10457, USA., Kumar K; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA., Chime C; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA., Patel H; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA., Kamal MU; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA., Shaikh D; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA., Vootla V; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA., Bajantri B; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA., Gomceli U; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Cardiology Bronx, NY 10457, USA., Alshelleh M; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA., Peralta R; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA., Zhang A; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA., Chilimuri S; Bronx Care Health System, Department of Medicine Bronx, NY 10457, USA.; Bronx Care Health System, Division of Gastroenterology Bronx, NY 10457, USA.
Jazyk:	angličtina
Zdroj:	American journal of cardiovascular disease [Am J Cardiovasc Dis] 2019 Oct 15; Vol. 9 (5), pp. 65-77. Date of Electronic Publication: 2019 Oct 15 (Print Publication: 2019).
Abstrakt:	Background: Metabolic syndrome is associated with preclinical cardiac disease and nonalcoholic fatty liver disease (NAFLD). It is uncertain whether preclinical cardiac disease is present in patients with NAFLD without metabolic syndrome (MetS). Objective: To explore preclinical cardiac disease in patients with NAFLD. Methods: A total of 64 patients with NAFLD, based on computed tomography scans liver attenuation, were identified. A control group, matched to age and gender, comprising of 94 patients was also drafted. Finally, two additional groups of patients with metabolic syndrome, with (n = 40) and without (n = 74) NAFLD, were also identified. Patients with hypertension, diabetes mellitus, and other concomitant liver diseases were excluded from the NAFLD group. Echocardiograms of all groups were reviewed. Results: Severe NAFLD compared to control was associated with a higher left ventricular mass after normalization for height 2.7 (LVMHt 2.7 ) (95% CI = 0.39, 12.92) and lower ratio of peak "E" (early) and "A" (late) diastolic ventricular filling velocities (E/A) - 0.39 (95% CI = -0.58, -0.19). Patients with metabolic syndrome (95% CI = 0.02, 0.09), metabolic syndrome with NAFLD (95% CI = 0.02, 0.08), or severe NAFLD (95% CI = 0.02, 0.09) compared to control was associated with a higher relative wall thickness (RWT). Conclusion: Healthy adults with NAFLD without metabolic syndrome, after adjusting for body mass index, demonstrated significant echocardiographic changes. Our results show that NAFLD is associated with preclinical cardiac disease, and this association is independent of traditional risk factors like systemic hypertension and diabetes mellitus. Competing Interests: None. (AJCD Copyright © 2019.)
Databáze:	MEDLINE
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