Peripheral neuropathies in rheumatic diseases: More diverse and frequent than expected. A cross-sectional study.

Autor: López-López CO; Rehabilitation Department, Hospital General de México, Mexico City, Mexico., Montes Castillo ML; Rehabilitation Department, Hospital General de México, Mexico City, Mexico., Soto-Fajardo RC; Universidad Nacional Autónoma de México, Mexico City, Mexico., Sandoval-García LF; Rheumatology Department, Hospital General de México, Mexico City, Mexico., Loyola-Sánchez A; Division of Physical Medicine and Rehabilitation, University of Alberta, Edmonton, Canada., Burgos-Vargas R; Rheumatology Department, Hospital General de México, Mexico City, Mexico., Peláez-Ballestas I; Rheumatology Department, Hospital General de México, Mexico City, Mexico., Álvarez Hernández E; Rheumatology Department, Hospital General de México, Mexico City, Mexico., Vázquez-Mellado J; Rheumatology Department, Hospital General de México, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2020 Feb; Vol. 23 (2), pp. 226-232. Date of Electronic Publication: 2019 Nov 24.
DOI: 10.1111/1756-185X.13755
Abstrakt: Background/objective: Peripheral neuropathies (PN) are heterogeneous nerve disorders; frequently rheumatic patients have neuropathic symptoms. In some rheumatic diseases (RD) PN are secondary to nerve compression while others are related to metabolic abnormalities, inflammation or vasculitis. Our aim was to explore the frequency of neuropathic symptoms with three neuropathy questionnaires (NQ) and nerve conduction studies (NCS) in RD.
Methods: This is a cross-sectional study in patients with any RD attending for the first time to a rheumatology outpatient clinic. We included all patients who accepted to participate and who answered three NQ and received a physical evaluation. Twenty patients were randomly selected to perform NCS and 10 healthy subjects were included as controls. The topographic diagnoses were: mononeuropathy, multiplex mononeuropathy, and/or polyneuropathy.
Statistical Analysis: descriptive statistics (mean, median, standard deviation, interquartile range and frequency, odds ratios and Pearson correlation test).
Results: One hundred patients and 10 healthy subjects were included. Sixty-nine were female, mean age 40.6 ± 15.7 years. Rheumatic diagnoses were: systemic lupus erythematosus (26%), rheumatoid arthritis (16%), gout (14%), and osteoarthritis (11%). Fifty-two patients had neuropathic signs during physical examination and 67% had positive questionnaires with variable scores among several RD. Abnormal NCS was reported in 14 patients (70%): 6 (42.8%) median nerve mononeuropathies, 4 (28.5%) multiplex mononeuropathies and 4 (28.5%) polyneuropathies. None of the healthy subjects had neuropathy (NQ, physical evaluation, or NCS). Risk of being NCS positive is higher when the patients were NQ positive.
Conclusion: PN has variable distribution and high frequency in patients with RD; NQ+ increases the risk of presenting NCS+ for PN.
(© 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje