| Autor: |
Kalinina EV; Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russia. kalinina-ev@rudn.ru., Ivanova-Radkevich VI; Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russia., Chernov NN; Peoples' Friendship University of Russia (RUDN University), Moscow, 117198, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2019 Nov; Vol. 84 (11), pp. 1233-1246. |
| DOI: |
10.1134/S0006297919110026 |
| Abstrakt: |
Cellular redox homeostasis involves a combination of redox processes and corresponding regulatory systems and represents an important factor ensuring cell viability. Redox-dependent regulation of cellular processes is a multi-level system including not only proteins and enzyme complexes, but also non-coding RNAs, among which an important role belongs to microRNAs. The review focuses on the involvement of miRNAs in the redox-dependent regulation of both ROS (reactive oxygen species)-generating enzymes and antioxidant enzymes with special emphasis on the effects of miRNAs on redox-dependent processes in tumor cells. The impact of ROS on the miRNA expression and the role of the ROS/miRNA feedback regulation in the cell redox state are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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