Characterization of High-risk Oncogenic Human Papillomavirus Genotypes in Histologically Confirmed Ear, Nose and Throat (Ent) Cancers in Burkina Faso.

Autor:	Ilboudo M; Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso., Zohoncon TM; Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso., Traore EMA; Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso., Traore IMA; Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso., Kande A; Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso., Djigma FW; Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso., Obiri-Yeboah D; University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03; University Hospital Yalgado OUEDRAOGO Burkina Faso., Gyebre YMC; University of Cape Coast, School of Medical Sciences, Department of Microbiology and Immunology, University Post Office, Ghana., Simpore J; Laboratory of Molecular Biology and Genetics (LABIOGENE), University Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.; Pietro Annigoni Biomolecular Research Center (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso.
Jazyk:	angličtina
Zdroj:	Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2019 Nov 01; Vol. 20 (11), pp. 3429-3435. Date of Electronic Publication: 2019 Nov 01.
DOI:	10.31557/APJCP.2019.20.11.3429
Abstrakt:	Background: High-risk human papillomavirus (HPV-HR) infections are responsible for 99.99% of cervico-uterine cancers and 50% of carcinomas of the oropharynx. Objective: To characterize high-risk HPV genotypes (HPV-HR) in histologically confirmed ear, nose and throat (ENT) cancers in Ouagadougou. Methods: One hundred and twenty-eight archived tissues from the ENT sphere, obtained over the last ten years (2007 to 2017) and histologically diagnosed in anatomy and pathology-cytology laboratories in Ouagadougou were included. These tissues were dewaxed with xylene; HPV DNA extraction was performed and HPV-HR were researched by real-time multiplex PCR. Results: Among the fourteen HPV-HR genotypes tested for, seven were identified. The prevalence of HPV-HR infection was 15.6%. The most common genotypes were: HPV56 (45%) and HPV33 (20%). Squamous cell carcinomas accounted for 75% of cases, followed by lymphomas for 10%. The age range was between 5 and 80 years. Conclusion: The results show the involvement of a diversity of HPV-HR genotypes and a high frequency of HPV56 and HPV33 in ENT cancers in Ouagadougou, Burkina Faso. The appropriate HPV vaccination will considerably reduce the number of these cancers. .
Databáze:	MEDLINE
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