Diagnostic accuracy of 99m Tc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis.

Autor:	Plate A; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland. Electronic address: andreas.plate@usz.ch., Weichselbaumer V; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Schüpbach R; Department of Orthopaedics, University Hospital Balgrist, University of Zurich, Forchstrasse 340, Zurich, 8008 Switzerland., Fucentese SF; Department of Orthopaedics, University Hospital Balgrist, University of Zurich, Forchstrasse 340, Zurich, 8008 Switzerland., Berli M; Department of Orthopaedics, University Hospital Balgrist, University of Zurich, Forchstrasse 340, Zurich, 8008 Switzerland., Hüllner M; Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland., Achermann Y; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2020 Feb; Vol. 91, pp. 79-86. Date of Electronic Publication: 2019 Nov 20.
DOI:	10.1016/j.ijid.2019.11.017
Abstrakt:	Objectives: Conventional imaging techniques are routinely used in the diagnostic work-up of patients with suspected osteomyelitis or orthopaedic implant-associated infections. Hybrid nuclear medicine imaging techniques are a suitable alternative to routine imaging modalities as they provide anatomical and functional information within one procedure. Our study investigated the performance of anti-granulocyte SPECT/CT using 99m Tc-labelled monoclonal antibodies in the diagnosis of osteomyelitis and orthopaedic implant-associated infections. Methods: In this retrospective analysis, we included patients with 99m Tc-antigranulocyte SPECT/CT acquired in the context of a suspected bone and joint infection. All patients underwent routine diagnostics and/or had a clinical follow-up of at least 12months. Results: 26 episodes were included. Fifteen exams were performed for suspected osteomyelitis, and 11 for suspected orthopaedic implant-associated infection. SPECT/CT was ordered most often if standard diagnostic tests or conventional imaging modalities remained inconclusive. The overall sensitivity and specificity for the diagnosis of an infection were 77.8% and 94.1%, respectively. The positive predictive value was 87.5% and the negative predictive value 88.9%. Diagnostic accuracy was 88.5%. Conclusions: 99m Tc-antigranulocyte SPECT/CT imaging has a high accuracy in the diagnosis of osteomyelitis and orthopaedic implant-associated infections and is a suitable non-invasive diagnostic tool if standard diagnostic examinations are inconclusive or not applicable. (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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