Efficacy of curcumin in the treatment of experimental vulvovaginal candidiasis.

Autor: Andrade JT; Laboratory of Medical Microbiology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil., Fantini de Figueiredo G; Laboratory of Pharmacology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil., Cruz LF; Laboratory of Pharmacology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil., Eliza de Morais S; Laboratory of Pharmacology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil., Souza CDF; Laboratory of Medical Microbiology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil., Pinto FCH; Natural Sciences Departament, Federal University of São João Del-Rei, Campus Dom Bosco, São João Del-Rei, Minas Gerais, Brazil., Ferreira JMS; Laboratory of Medical Microbiology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil., Araújo MGF; Laboratory of Pharmacology, Federal University of São João Del-Rei, Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil. Electronic address: mgfaraujo@ufsj.edu.br.
Jazyk: angličtina
Zdroj: Revista iberoamericana de micologia [Rev Iberoam Micol] 2019 Oct - Dec; Vol. 36 (4), pp. 192-199. Date of Electronic Publication: 2019 Nov 19.
DOI: 10.1016/j.riam.2019.01.003
Abstrakt: Background: Candida albicans is the main agent that causes vulvovaginal candidiasis. Resistance among isolates to azole antifungal agents has been reported.
Aims: Due to the well-known antifungal potential of curcumin, the purpose of this work was to evaluate the in vitro anticandidal activity of curcumin and its effect in the treatment of experimental vulvovaginal candidiasis.
Methods: The anticandidal activity of curcumin was investigated against eight Candida strains by the broth microdilution assay, and its mechanism of action was evaluated by testing the binding to ergosterol. Then, the effect of curcumin in the treatment of vulvovaginal candidiasis was evaluated in an immunosuppressed, estrogen treated rat model.
Results: Curcumin showed minimum inhibitory concentration values of 125-1000μg/ml, and the best result was observed against Candida glabrata. The compound was shown to be able to bind to the ergosterol present in the membrane, event that may be the mechanism of action. In addition, in the in vivo model of vulvovaginal candidiasis with C. albicans, treatments reduced the vaginal fungal burden in infected rats after seven days of treatment with different doses.
Conclusions: Curcumin could be considered a promising effective antifungal agent in the treatment of vulvovaginal candidiasis.
(Copyright © 2019 Asociación Española de Micología. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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