Quantification of brain proton longitudinal relaxation (T 1 ) in lithium-treated and lithium-naïve patients with bipolar disorder in comparison to healthy controls.

Autor: Necus J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Interdisciplinary Computing and Complex BioSystems (ICOS), School of Computing Science, Newcastle University, Newcastle upon Tyne, UK., Smith FE; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK., Thelwall PE; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK., Flowers CJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Sinha N; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Interdisciplinary Computing and Complex BioSystems (ICOS), School of Computing Science, Newcastle University, Newcastle upon Tyne, UK., Taylor PN; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Interdisciplinary Computing and Complex BioSystems (ICOS), School of Computing Science, Newcastle University, Newcastle upon Tyne, UK.; Institute of Neurology, University College London, London, UK., Blamire AM; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK., Wang Y; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Interdisciplinary Computing and Complex BioSystems (ICOS), School of Computing Science, Newcastle University, Newcastle upon Tyne, UK.; Institute of Neurology, University College London, London, UK., Cousins DA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK.
Jazyk: angličtina
Zdroj: Bipolar disorders [Bipolar Disord] 2021 Feb; Vol. 23 (1), pp. 41-48. Date of Electronic Publication: 2019 Dec 02.
DOI: 10.1111/bdi.12878
Abstrakt: Background: Proton longitudinal relaxation (T 1 ) is a quantitative MRI-derived tissue parameter sensitive to myelin, macromolecular, iron and water content. There is some evidence to suggest that cortical T 1 is elevated in bipolar disorder and that lithium administration reduces cortical T 1 . However, T 1 has not yet been quantified in separate groups containing lithium-treated patients, lithium-naïve patients, and matched healthy controls.
Methods: Euthymic patients with bipolar disorder receiving lithium (n = 18, BDL) and those on other medications but naïve to lithium (n = 20, BDC) underwent quantitative T 1 mapping alongside healthy controls (n = 18, HC). T 1 was compared between groups within the cortex, white matter and subcortical structures using regions of interest (ROI) derived from the Desikan-Killiany atlas. Effect sizes for each ROI were computed for BDC vs BDL groups and Bipolar Disorder vs HC groups.
Results: No significant differences in T 1 were identified between BDL and BDC groups when corrected for multiple comparisons. Patients with bipolar disorder had significantly higher mean T 1 in a range of ROIs compared to healthy controls, including bilateral motor, somatosensory and superior temporal regions, subcortical structures and white matter.
Conclusions: The higher T 1 values observed in the patients with bipolar disorder may reflect abnormal tissue microstructure. Whilst the precise mechanism remains unknown, these findings may have a basis in differences in myelination, macromolecular content, iron and water content between patients and controls.
(© 2019 The Authors. Bipolar Disorders published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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