A Novel Approach to the Treatment of Pembrolizumab-induced Psoriasis Exacerbation: A Case Report.
| Autor: | Monsour EP; Internal Medicine, University of Central Florida / Ocala Regional Medical Center, Ocala, USA., Pothen J; Internal Medicine, General Medical Education, Ocala Regional Medical Center, Ocala, USA., Balaraman R; Hematology and Oncology, Florida Cancer Affiliates / Ocala Oncology, Ocala, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2019 Oct 02; Vol. 11 (10), pp. e5824. Date of Electronic Publication: 2019 Oct 02. |
| DOI: | 10.7759/cureus.5824 |
| Abstrakt: | While immune checkpoint inhibitors have been groundbreaking for cancer treatment, there are many reported cases of patients undergoing immunotherapy who have discontinued or temporarily interrupted treatment due to the development of autoimmune-related adverse effects. Here, we present a 63-year-old female with a history of psoriasis (in spontaneous remission) and newly diagnosed poorly differentiated lung adenocarcinoma (pTXN3M1a) who experienced a severe flare-up of her psoriasis three months after initiating single-agent pembrolizumab. The patient was initially treated with topical clobetasol propionate ointment, however, due to minimal response to this regimen, the patient was commenced on secukinumab; an IL-17 inhibitor. To our knowledge, this is the first case of the successful use of secukinumab for the treatment of immunotherapy-induced psoriasis. More importantly, immunotherapy with pembrolizumab was continued successfully with the co-administration of secukinumab without complications or the recurrence of non-small cell lung cancer (NSCLC). Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2019, Monsour et al.) |
| Databáze: | MEDLINE |
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