Pharmacokinetic study of intravenously administered artemisinin-loaded surface-decorated amphiphilic γ-cyclodextrin nanoparticles.
Autor: | Gérard Yaméogo JB; Univ. Grenoble Alpes, CNRS, DPM, F-38000, Grenoble, France; UFR/SDS, University Ouaga I Pr Joseph Ki-Zerbo, Burkina Faso., Mazet R; Univ. Grenoble Alpes, CNRS, DPM, F-38000, Grenoble, France; Pôle Pharmacie, Grenoble University Hospital, 38000, Grenoble, France., Wouessidjewe D; Univ. Grenoble Alpes, CNRS, DPM, F-38000, Grenoble, France., Choisnard L; Univ. Grenoble Alpes, CNRS, DPM, F-38000, Grenoble, France., Godin-Ribuot D; Laboratoire HP2/U1042 INSERM, Faculty of Pharmacy, Univ. Grenoble Alpes, France., Putaux JL; Univ. Grenoble Alpes, CNRS, CERMAV, F-38000, Grenoble, France., Semdé R; UFR/SDS, University Ouaga I Pr Joseph Ki-Zerbo, Burkina Faso., Gèze A; Univ. Grenoble Alpes, CNRS, DPM, F-38000, Grenoble, France. Electronic address: annabelle.geze@univ-grenoble-alpes.fr. |
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Jazyk: | angličtina |
Zdroj: | Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Jan; Vol. 106, pp. 110281. Date of Electronic Publication: 2019 Oct 07. |
DOI: | 10.1016/j.msec.2019.110281 |
Abstrakt: | Artemisinin and its derivatives are currently recommended by World Health Organization for the treatment of malaria. Severe malaria requires a parenteral administration of artemisinin-based formulations. However, the effective use of artemisinin is limited by the pharmacokinetic characteristics of the drug (low water solubility, poor bioavailability and short half-life). To overcome some of these drawbacks, artemisinin-loaded surface-decorated nanoparticles were prepared by co-nanoprecipitation of γ-cyclodextrin bioesterified with C (Copyright © 2019 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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