Chronic Thrombo-Embolic Pulmonary Hypertension

Autor: Sabbula BR; Nassau University Medical Center, Akella J
Jazyk: angličtina
Zdroj: 2022 Jan.
Abstrakt: Chronic thromboembolic pulmonary hypertension (CTEPH) is a potentially life-threatening condition and is associated with high morbidity and mortality.[1] However, advances in medical and surgical treatments have markedly improved the outcomes.[2][3] Acute pulmonary embolism in a few cases in combination with other risk factors like prothrombotic tendencies, recurrent thromboemboli, genetic, and intrinsic factors may progress to chronic thromboembolic disease. Chronic thromboembolism often results in CTEPH and overt right heart failure. Thus, a low threshold is necessary for these patients to monitor for developing CTEPH. CTEPH will eventually lead to a significant limitation of functional capacity secondary to worsening hemodynamics and ultimately cause premature death if the disease is left to run its natural course without intervening. Chronic thromboembolism differs from CTEPH by the presence of resting pulmonary hypertension, a situation not seen in chronic thromboembolic disease.[4] CTEPH comes under group four of the World Health Organization classification of pulmonary hypertension.
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Databáze: MEDLINE