[The content of vascular endothelial grow factor in saliva and serum in patients with periodontitis.]

Autor:	Sosnin DY; Federal State Budgetary Educational Institution of Higher Education «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation, 614990, Perm, Russian Federation., Gileva OS; Federal State Budgetary Educational Institution of Higher Education «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation, 614990, Perm, Russian Federation., Sivak EY; Federal State Budgetary Educational Institution of Higher Education «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation, 614990, Perm, Russian Federation., Daurova FY; Peoples Friendship University of Russia, 117198, Moscow, Russian Federation., Gibadullina NV; Federal State Budgetary Educational Institution of Higher Education «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation, 614990, Perm, Russian Federation., Korotin SV; Federal State Budgetary Educational Institution of Higher Education «Academician Ye.A. Vagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation, 614990, Perm, Russian Federation.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2019; Vol. 64 (11), pp. 663-668.
DOI:	10.18821/0869-2084-2019-64-11-663-668
Abstrakt:	To study the concentration of vasculoendothelial growth factor (VEGF) in mixed saliva and serum of patients in normal conditions and with generalized periodontitis. The main group (n = 42) was represented by patients with generalized periodontitis. The comparison group (n = 36) consisted of patients without periodontal tissue diseases. The concentration of VEFR was determined by the method of enzyme-linked immunosorbent assay (ELISA) using a commercial test-system "VEGF - IFA - BEST" (A-8784) ("Vector - Best", Russia). The median values VEFR in saliva were 5.49 times higher than the values for serum in the main group (p = 0.000000) and 7.01 times in the comparison group (p = 0.000000). The concentration of VEFR in the saliva of the examined main group exceeded the similar values of the comparison group (p = 0,014857); the median and interquartile range for the main group was 1098.45 (925.5; 1291) pg/ml, and for the comparison group 1360.5 (998.9; 2062) pg/ml. There were no differences in the serum VEFR concentration (p = 0.775124). No significant correlation was found between the serum VEFR content and the mixed saliva. The Spearman's rank correlation coefficient for the main group was R = 0,0184358, and for the comparison group, respectively, R = 0.188932. The source of VEFR in saliva are the glands and cells of the oral mucosa, and not the process of exudation from blood serum. The high content of VEFR in the saliva of healthy people and a decrease in its level during periodontitis indicates the important role of this protein in the processes of maintaining the normal state of periodontal tissues and reparation of tissues of the oral mucosa. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu