The role of adiponectin in placentation and preeclampsia.

Autor: Adu-Gyamfi EA; Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.; Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, People's Republic of China., Fondjo LA; Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Republic of Ghana., Owiredu WKBA; Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Republic of Ghana., Czika A; Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.; Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, People's Republic of China., Nelson W; Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.; Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, People's Republic of China., Lamptey J; Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.; Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, People's Republic of China., Wang YX; Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.; Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, People's Republic of China., Ding YB; Department of Reproductive Sciences, School of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.; Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, People's Republic of China.
Jazyk: angličtina
Zdroj: Cell biochemistry and function [Cell Biochem Funct] 2020 Jan; Vol. 38 (1), pp. 106-117. Date of Electronic Publication: 2019 Nov 19.
DOI: 10.1002/cbf.3458
Abstrakt: Preeclampsia is not fully understood; and few biomarkers, therapeutic targets, and therapeutic agents for its management have been identified. Original investigative findings suggest that abnormal placentation triggers preeclampsia and leads to hypertension, proteinuria, endothelial dysfunction, and inflammation, which are characteristics of the disease. Because of the regulatory roles that it plays in several metabolic processes, adiponectin has become a cytokine of interest in metabolic medicine. In this review, we have discussed the role of adiponectin in trophoblast proliferation, trophoblast differentiation, trophoblast invasion of the decidua, and decidual angiogenesis, which are the major phases of placentation. Also, we have highlighted the physiological profile of adiponectin in the course of normal pregnancy. Moreover, we have discussed the involvement of adiponectin in hypertension, endothelial dysfunction, inflammation, and proteinuria. Furthermore, we have summarized the reported relationship between the maternal serum adiponectin level and preeclampsia. The available evidence indicates that adiponectin level physiologically falls as pregnancy advances, regulates placentation, and exhibits protective effects against the symptoms of preeclampsia and that while hyperadiponectinemia is evident in normal-weight preeclamptic women, hypoadiponectinemia is evident in overweight and obese preeclamptic women. Therefore, the clinical use of adiponectin as a biomarker, therapeutic target, or therapeutic agent against the disease looks promising and should be considered.
(© 2019 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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