Contemporary prostate cancer treatment choices in multidisciplinary clinics referenced to national trends.

Autor: Tang C; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Hoffman KE; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Allen PK; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Gabel M; Department of Radiation Oncology, Summit Medical Group, Summit, New Jersey., Schreiber D; Department of Radiation Oncology, Summit Medical Group, Summit, New Jersey., Choi S; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Chapin BF; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Nguyen QN; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Davis JW; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Corn P; Department of genitourinary medical oncology, The University of Texas MD Anderson cancer center, Houston, Texas., Logothetis C; Department of genitourinary medical oncology, The University of Texas MD Anderson cancer center, Houston, Texas., Ward J; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Frank SJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Navai N; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas., McGuire SE; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Anscher M; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Pisters L; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Pettaway CA; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kumar R; Banner MD Anderson Cancer Center, Mesa, Arizona., Linson P; Scripps MD Anderson Cancer Center, San Diego, California., Tripuraneni P; Scripps MD Anderson Cancer Center, San Diego, California., Tomaszewski JJ; Department of Urology, MD Anderson Center at Cooper, Camden, New Jersey., Patel AB; MD Anderson Cancer Center at Cooper, Camden, New Jersey., Augspurger M; Baptist MD Anderson Cancer Center, Jacksonville, Florida., Kuban DA; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jazyk: angličtina
Zdroj: Cancer [Cancer] 2020 Feb 01; Vol. 126 (3), pp. 506-514. Date of Electronic Publication: 2019 Nov 19.
DOI: 10.1002/cncr.32570
Abstrakt: Background: The purpose of this study was to assess treatment choices among men with prostate cancer who presented at The University of Texas MD Anderson Cancer Center multidisciplinary (MultiD) clinic compared with nationwide trends.
Methods: In total, 4451 men with prostate cancer who presented at the MultiD clinic from 2004 to 2016 were analyzed. To assess nationwide trends, the authors analyzed 392,710 men with prostate cancer who were diagnosed between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. The primary endpoint was treatment choice as a function of pretreatment demographics.
Results: Univariate analyses revealed similar treatment trends in the MultiD and SEER cohorts. The use of procedural forms of definitive therapy decreased with age, including brachytherapy and prostatectomy (all P < .05). Later year of diagnosis/clinic visit was associated with decreased use of definitive treatments, whereas higher risk grouping was associated with increased use (all P < .001). Patients with low-risk disease treated at the MultiD clinic were more likely to receive nondefinitive therapy than patients in SEER, whereas the opposite trend was observed for patients with high-risk disease, with a substantial portion of high-risk patients in SEER not receiving definitive therapy. In the MultiD clinic, African American men with intermediate-risk and high-risk disease were more likely to receive definitive therapy than white men, but for SEER the opposite was true.
Conclusions: Presentation at a MultiD clinic facilitates the appropriate disposition of patients with low-risk disease to nondefinitive strategies of patients with high-risk disease to definitive treatment, and it may obviate the influence of race.
(© 2019 American Cancer Society.)
Databáze: MEDLINE
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