Mapping the impact of exposure to maternal immune activation on juvenile Wistar rat brain macro- and microstructure during early post-natal development.

Autor:	Wood TC; Centre for Neuroimaging Sciences, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Edye ME; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Harte MK; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Neill JC; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Prinssen EP; Roche Innovation Centre Basel, Grenzacherstrasse, Switzerland., Vernon AC; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, Guy's Hospital Campus, King's College London, London, UK.
Jazyk:	angličtina
Zdroj:	Brain and neuroscience advances [Brain Neurosci Adv] 2019 Jan 01; Vol. 3, pp. 2398212819883086. Date of Electronic Publication: 2019 Nov 04.
DOI:	10.1177/2398212819883086
Abstrakt:	Maternal immune activation is consistently associated with elevated risk for multiple psychiatric disorders in the affected offspring. Related to this, an important goal of our work is to explore the impact of maternal immune activation effects across the lifespan. In this context, we recently reported the effects of polyriboinosinic-polyribocytidylic acid-induced maternal immune activation at gestational day 15, immediately prior to birth, at gestational day 21 and again at post-natal day 21, providing a systematic assessment of plasma interleukin 6, body temperature and weight alterations in pregnant rats and preliminary evidence for gross morphological changes and microglial neuropathology in both male and female offsprings at these time points. Here, we sought to complement and extend these data by characterising in more detail the mesoscale impact of gestational polyriboinosinic-polyribocytidylic acid exposure at gestational day 15 on the neuroanatomy of the juvenile (post-natal day 21) rat brain using high-resolution, ex vivo anatomical magnetic resonance imaging in combination with atlas-based segmentation. Our preliminary data suggest subtle neuroanatomical effects of gestational polyriboinosinic-polyribocytidylic acid exposure (n = 10) relative to saline controls (n = 10) at this time-point. Specifically, we found an increase in the relative volume of the diagonal domain in polyriboinosinic-polyribocytidylic acid offspring (p < 0.01 uncorrected), which just failed to pass stringent multiple comparisons correction (actual q = 0.07). No statistically significant microstructural alterations were detectable using diffusion tensor imaging. Further studies are required to map the proximal effects of maternal immune activation on the developing rodent brain from foetal to early post-natal life and confirm our findings herein. Competing Interests: Declaration of conflicting interests ACV discloses receiving financial support from UCB Biopharma, not related to this study. ACV and JCN disclose recieving financial support for this study from F. Hoffman La Roche Ltd. The funder had no role in the decision to publish this work. The funders had no role in the decision to publish this work M.E.E., T.C.W. and M.K.H. declare no conflicts of interest. E.P.P. is a full-time employee of F. Hoffman La Roche Ltd.
Databáze:	MEDLINE
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