Association between ANGPTL-4 and the proinflammatory process in cancer cachexia patients.

Autor:	Neto NIP; Departamento de Fisiologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil., Boldarine VT; Departamento de Fisiologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil., Hachul ACL; Departamento de Fisiologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil., Oyama LM; Departamento de Fisiologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil., Lima JDCC; Institute of Biomedical Sciences, Cancer Metabolism Research Group, University of São Paulo, São Paulo, Brazil., Fernandez ES; Institute of Biomedical Sciences, Cancer Metabolism Research Group, University of São Paulo, São Paulo, Brazil., Otoch JP; Department of Clinical Surgery, University of São Paulo, São Paulo, Brazil., de Alcântara PSM; Department of Clinical Surgery, University of São Paulo, São Paulo, Brazil., Tokeshi F; Department of Clinical Surgery, University of São Paulo, São Paulo, Brazil., Seelaender MCL; Department of Clinical Surgery, University of São Paulo, São Paulo, Brazil.; Institute of Biomedical Sciences, Cancer Metabolism Research Group, University of São Paulo, São Paulo, Brazil., Oller do Nascimento CMDP; Departamento de Fisiologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2019 Nov 05; Vol. 10 (60), pp. 6444-6455. Date of Electronic Publication: 2019 Nov 05 (Print Publication: 2019).
DOI:	10.18632/oncotarget.27269
Abstrakt:	Background: Contradictory results are reported for the role of angiopoietin-like 4 (ANGPTL-4) in the development of cancer-cachexia and inflammation, given its importance in angiogenesis and inflammatory signaling. Our aim was to analyze the levels of ANGPTL-4 in colorectal cancer patients with a stable weight and those with cachexia in order to establish a relationship between ANGPTL-4 and the inflammatory process. Results: Plasma and tumor levels of ANGPTL-4 were higher in CC in comparison to other groups. A positive association was verified between plasmatic ANGPTL-4 and NFκB levels in tumor from CC. In WSC, we identified an association between the plasmatic ANGPTL-4, IL-15, and IL-10 in tumor and IL-15 in MES. Increased levels of NFκB and TNF-R1 in MES were detected in CC in comparison to WSC. Specifically in CC-group, a positive correlation was found between ANGPTL-4 levels and those of IL-1β, TNF-α, and NFκB in tumor, along with an association between ANGPTL-4 levels with IL-1β and MCP-1 levels in tumor; and ANGPTL-4 and IL-1β levels in MES. Methods: We studied 102 patients, who were divided into three groups: control patients (C, n=37), cancer patients with a stable weight (WSC, n=23), and cancer-cachexia patients (CC, n=42). Samples of plasma, tumor, mesenteric (MES) and subcutaneous adipose tissue were removed for the determination of ANGPTL-4 levels and other proinflammatory factors. Conclusions: ANGPTL-4 levels were higher in plasma and tumor of CC-group, and positively associated with pro-inflammatory and pro-tumorigenic factors. Our results suggest an opposite effect of ANGPTL-4 depending on the concentration and presence of cachexia. Competing Interests: CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest. (Copyright: Neto et al.)
Databáze:	MEDLINE
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