Left Ventricular Regional Function in Children with Beta Thalassemia with No Cardiac Manifestations (Four-Dimensional Echocardiographic Study).

Autor: El Razaky OA; 1Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt., El-Shanshory MR; 1Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt., El-Shehaby WA; 1Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt., Hables NM; 1Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt., Elshamia AM; 2Ministry of Health, Cairo, Egypt., Fayed AM; 2Ministry of Health, Cairo, Egypt., El-Kholy AE; 2Ministry of Health, Cairo, Egypt., El-Dosoky EA; 2Ministry of Health, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion [Indian J Hematol Blood Transfus] 2019 Oct; Vol. 35 (4), pp. 750-757. Date of Electronic Publication: 2019 Mar 22.
DOI: 10.1007/s12288-019-01117-6
Abstrakt: Early detection of myocardial dysfunction is essential for the management of patients with thalassemia. Four-dimensional echocardiography imaging technique may be useful for detecting subclinical cardiovascular disease. To evaluate the 4-dimensional echocardiographic strain in children with beta thalassemia major with no cardiac manifestation and correlate it with other echocardiographic parameters. This is a prospective cross-sectional cohort Study included 200 children, 1-18 years-old. They were divided into: One hundred children with p-Thalassemia major with no clinical cardiac manifestations and 100 healthy children as a control group. They were subjected to the following investigations: Complete blood count, serum ferritin and Four-dimensional echocardiographic strains (Longitudinal, Circumferential, Radial and Area strains). There was no significant difference between the two groups as regard mitral annulus systolic velocity (S wave), E/A ratio and iso-volumic acceleration, but there was a significant difference as regard to ejection fraction, left ventricle mass, sphericity index and myocardial performance index. The mean values of Left Ventricular Strains (Longitudinal, Circumferential, Radial and Area strains) were significantly lower in patients with thalassemia (- 14.86 ± 12.13, - 8.01 ± 3.829, 33.13 ± 10.61, - 19.45 ± 6.866) than controls (- 19.13 ± 1.502, - 16.32 ± 1.34, 37.28 ± 4.209, - 22.94 ± 3.06) than controls respectively with a positive correlation with 2-Dimensional strain. Strain parameters of the left ventricle obtained by four-dimensional.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest.
(© Indian Society of Hematology and Blood Transfusion 2019.)
Databáze: MEDLINE
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