Inflammasomes: Their Role in Normal and Complicated Pregnancies.

Autor:	Gomez-Lopez N; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, and Detroit, MI 48201; nardhy.gomez-lopez@wayne.edu.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201.; Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201., Motomura K; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, and Detroit, MI 48201.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201., Miller D; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, and Detroit, MI 48201.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201., Garcia-Flores V; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, and Detroit, MI 48201.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201., Galaz J; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, and Detroit, MI 48201.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201., Romero R; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, and Detroit, MI 48201.; Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109.; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824.; Center for Molecular Obstetrics and Genetics, Wayne State University, Detroit, MI 48201.; Detroit Medical Center, Detroit, MI 48201; and.; Department of Obstetrics and Gynecology, Florida International University, Miami, FL 33199.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Dec 01; Vol. 203 (11), pp. 2757-2769.
DOI:	10.4049/jimmunol.1900901
Abstrakt:	Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory responses, including those that take place during pregnancy. Inflammasomes and their downstream mediators caspase-1 and IL-1β are expressed by gestational tissues (e.g., the placenta and chorioamniotic membranes) during normal pregnancy. Yet, only the activation of the NLRP3 inflammasome in the chorioamniotic membranes has been partially implicated in the sterile inflammatory process of term parturition. In vivo and ex vivo studies have consistently shown that the activation of the NLRP3 inflammasome is a mechanism whereby preterm labor and birth occur in the context of microbial- or alarmin-induced inflammation. In the placenta, the activation of the NLRP3 inflammasome is involved in the pathogenesis of preeclampsia and other pregnancy syndromes associated with placental inflammation. This evidence suggests that inhibition of the NLRP3 inflammasome or its downstream mediators may foster the development of novel anti-inflammatory therapies for the prevention or treatment of pregnancy complications. (Copyright © 2019 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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