| Autor: |
Okolie CE; Diagnostics for One Health, Department of Microbiology , College of Pure and Applied Sciences, Landmark University , Km 4 Ipetu Road , Omu-Aran , Kwara State , Nigeria 251101., Essien UC; Department of Medical Laboratory Science, Faculty of Allied Sciences, College of Medical and Health Sciences , University of Jos , Jos , Plateau State , Nigeria 930222. |
| Jazyk: |
angličtina |
| Zdroj: |
ACS infectious diseases [ACS Infect Dis] 2019 Dec 13; Vol. 5 (12), pp. 1980-1986. Date of Electronic Publication: 2019 Nov 18. |
| DOI: |
10.1021/acsinfecdis.9b00340 |
| Abstrakt: |
For longer than a century, the "meningitis belt" of sub-Saharan Africa has experienced the largest-ever global meningitis epidemic. Whereas HIV-associated immunosuppression drives higher susceptibility to environmental infectious organisms with tropism for the central nervous system (CNS), most diagnostic laboratories in the belt stick to N. meningitidis , H. influenzae , and S. pneumoniae . Cryptococcus neoformans has been the leading cause of death (incidence, 89%; death, 75%). To establish whether diagnostic services target geographically important pathogens, there is a need to know the current spectrum of etiology. Given Africa's agro-silvo-pastoralism, the One Health diagnostic approach is recommended. Considering multipathogen detection capacity, needed speed for corticosteroid therapy decision, and susceptibility/resistance to antimicrobials with improved CNS penetration, proposed laboratory categorization will help neurologists to choose suitable services. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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