Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases.
| Autor: | Uzun Ö; Department of Psychiatry, Gülhane Medical School., Bolu A; Department of Psychiatry, Gülhane Medical School., Taşçi AB; Department of Psychiatry, Gulhane Training and Research Hospital, Ankara, Turkey., Oğur B; Department of Psychiatry, Gulhane Training and Research Hospital, Ankara, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical neuropharmacology [Clin Neuropharmacol] 2020 Jan/Feb; Vol. 43 (1), pp. 26-27. |
| DOI: | 10.1097/WNF.0000000000000370 |
| Abstrakt: | Background: Negative myoclonus is rarely seen in the clinical setting. It can be involved in some central nervous system pathologies. It has also been observed after antipsychotic treatment. Case Reports: In this article, we will present 3 cases diagnosed with negative myoclonus in a 120-bed university-affiliated hospital within the past 7 years. Based on our clinical experience, it was observed that myoclonic jerk was a rare condition that started with suddenly dose changes. Patients showed good improvement in response to dose reduction. Conclusions: Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose. |
| Databáze: | MEDLINE |
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