Dissecting the functional outcomes of first episode schizophrenia spectrum disorders: a 10-year follow-up study in the PAFIP cohort.

Autor:	Ayesa-Arriola R; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain., Ortíz-García de la Foz V; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain., Martínez-García O; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain., Setién-Suero E; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain., Ramírez ML; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain., Suárez-Pinilla P; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain., Mayoral-van Son J; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.; Sierrallana Hospital, Torrelavega, Cantabria, Spain., Vázquez-Bourgon J; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain., Juncal-Ruiz M; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.; Sierrallana Hospital, Torrelavega, Cantabria, Spain., Gómez-Revuelta M; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain., Tordesillas-Gutiérrez D; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain., Crespo-Facorro B; Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.; CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2021 Jan; Vol. 51 (2), pp. 264-277. Date of Electronic Publication: 2019 Nov 18.
DOI:	10.1017/S0033291719003179
Abstrakt:	Background: The aim of the current study was to examine the heterogeneity of functional outcomes in first episode psychosis (FEP) patients and related clinical, neurocognitive and sociodemographic factors using a cluster analytic approach. Method: A large sample of FEP patients (N = 209) was functionally reassessed 10 years after the first contact with an early intervention service. Multiple baseline, 3-year and 10-year follow-up variables were explored. Results: The cluster analysis emphasized the existence of six independent clusters of functioning: one cluster was normal overall (42.16%), two clusters showed moderate interpersonal (9.63%) or instrumental (12.65%) deficits, two clusters showed more severe interpersonal (12.05%) or interpersonal and instrumental (13.85%) deficits and there was a significantly overall impaired cluster (9.63%). Cluster comparisons showed that several baseline and follow-up factors were differentially involved in functional outcomes. Conclusions: The current study demonstrated that distinct clusters of functioning in FEP patients can be identified. The fact that a variety of profiles was observed contributes to a better understanding of the nature of the heterogeneity characterizing FEP patients and has clinical implications for developing individualized treatment plans.
Databáze:	MEDLINE
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