Periodic Remodeling in a Neural Circuit Governs Timing of Female Sexual Behavior.

Autor:	Inoue S; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Yang R; Biology Program, Stanford University, Stanford, CA 94305, USA., Tantry A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Davis CH; Neurosciences Program, Stanford University, Stanford, CA 94305, USA., Yang T; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Knoedler JR; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Wei Y; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Adams EL; Neurosciences Program, Stanford University, Stanford, CA 94305, USA., Thombare S; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA., Golf SR; Neurosciences Program, Stanford University, Stanford, CA 94305, USA., Neve RL; Gene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA 02139, USA., Tessier-Lavigne M; Department of Biology, Stanford University, Stanford, CA 94305, USA., Ding JB; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA; Department of Neurology, Stanford University, Stanford, CA 94305, USA., Shah NM; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: nirao@stanford.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2019 Nov 27; Vol. 179 (6), pp. 1393-1408.e16. Date of Electronic Publication: 2019 Nov 14.
DOI:	10.1016/j.cell.2019.10.025
Abstrakt:	Behaviors are inextricably linked to internal state. We have identified a neural mechanism that links female sexual behavior with the estrus, the ovulatory phase of the estrous cycle. We find that progesterone-receptor (PR)-expressing neurons in the ventromedial hypothalamus (VMH) are active and required during this behavior. Activating these neurons, however, does not elicit sexual behavior in non-estrus females. We show that projections of PR+ VMH neurons to the anteroventral periventricular (AVPV) nucleus change across the 5-day mouse estrous cycle, with ∼3-fold more termini and functional connections during estrus. This cyclic increase in connectivity is found in adult females, but not males, and regulated by estrogen signaling in PR+ VMH neurons. We further show that these connections are essential for sexual behavior in receptive females. Thus, estrogen-regulated structural plasticity of behaviorally salient connections in the adult female brain links sexual behavior to the estrus phase of the estrous cycle. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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