Generation of two iPSC lines, (ICGi015-A and ICGi015-B), by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease.

Autor:	Sharipova DV; Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; E.N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia., Kovalenko VR; Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Bairamova EM; Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia., Vartanova VA; Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia., Grigor'eva EV; Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; E.N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia., Vyatkin YV; Novosibirsk State University, Novosibirsk, Russia; AcademGene LLC, Novosibirsk, Russia; St. Laurent Institute, Woburn, USA., Khabarova EA; Federal Neurosurgical Center, Novosibirsk, Russia., Rzaev DA; Federal Neurosurgical Center, Novosibirsk, Russia., Zakian SM; Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; E.N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia., Medvedev SP; Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia; E.N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia. Electronic address: cmedvedev@bionet.nsc.ru.
Jazyk:	angličtina
Zdroj:	Stem cell research [Stem Cell Res] 2019 Dec; Vol. 41, pp. 101652. Date of Electronic Publication: 2019 Nov 09.
DOI:	10.1016/j.scr.2019.101652
Abstrakt:	Studying Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, requires different model systems, including patient-specific induced pluripotent stem cell lines. With the help of non-integrating episomal vectors the iPSC lines ICGi015-A and ICGi015-B were generated from blood mononuclear cells of PD patient, carrying three SNPs, associated with PD development. The obtained iPSC lines express pluripotency markers and demonstrate the ability to in vitro differentiate into the three germ layers. These cell lines may be useful for studying molecular mechanisms of PD and for drug screening. (Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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