| Autor: |
Kulakov AA; First Sechenov Moscow State Medical University, Ministry of Health, 119991, Moscow, Russia.; Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of the Russian Federation, 119146, Moscow, Russia., Kogan EA; First Sechenov Moscow State Medical University, Ministry of Health, 119991, Moscow, Russia., Brailovskaya TV; First Sechenov Moscow State Medical University, Ministry of Health, 119991, Moscow, Russia.; Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of the Russian Federation, 119146, Moscow, Russia., Vedyaeva AP; First Sechenov Moscow State Medical University, Ministry of Health, 119991, Moscow, Russia. avedyaeva@yandex.ru.; Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of the Russian Federation, 119146, Moscow, Russia. avedyaeva@yandex.ru., Zharkov NV; First Sechenov Moscow State Medical University, Ministry of Health, 119991, Moscow, Russia. |
| Abstrakt: |
Morphological and immunohistochemical examination was made on 24 gum biopsies obtained from 35- to 60-year-old patients with diagnosis of partial secondary adentia, chronic generalized moderate to severe periodontitis (19 patients), as well as on the biopsy samples from five patients without pathological periodontal changes who underwent dental implantation. Serial paraffin sections were treated with antibodies against Ki-67, VEGF, and SMA. In patients with severe chronic periodontitis, a high proliferative activity of epithelium indicative of hyperplastic changes was observed, as well as a reduced number of the SMA-positive cells and actual absence of the SMA-positive cell couplings associated with the "growth zones" in tissues, which testifies indirectly to a lower tissue regenerative capacity. Hence, before dental implantation, additional anti-inflammatory and pro-regenerative treatment is required. |
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