| Autor: |
Anokhina IP; Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia., Anokhin PK; Serbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia., Kokhan VS; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. viktor_kohan@hotmail.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2019 Sep; Vol. 488 (1), pp. 133-135. Date of Electronic Publication: 2019 Nov 15. |
| DOI: |
10.1134/S0012496619050016 |
| Abstrakt: |
C/EBP-β, a basic leucine zipper transcription factor, has important roles in the regulation of the body immune and inflammatory responses. Wistar rats subjected to combined irradiation were characterized by an increase in the content of the C/EBP-β LIP isoform in the pituitary gland. The obtained data indicate that moderate doses of ionizing radiation to initiate the endoplasmic reticulum stress response and are likely to initiate C/EBP-β-mediated cell death according to the apoptotic scenario. This study also confirms the earlier hypothesis about the alterations of the hypothalamic-pituitary-adrenocortical axis in response to moderate doses of ionizing radiation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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