Ketogenic diet activates protective γδ T cell responses against influenza virus infection.

Autor:	Goldberg EL; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06519, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA., Molony RD; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.; Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA 02139, USA., Kudo E; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA., Sidorov S; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06519, USA., Kong Y; Department of Molecular Biophysics and Biochemistry, W.M. Keck Foundation Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, CT 06520, USA., Dixit VD; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06519, USA. vishwa.dixit@yale.edu akiko.iwasaki@yale.edu.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA.; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06519, USA., Iwasaki A; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06519, USA. vishwa.dixit@yale.edu akiko.iwasaki@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT, 06511, USA.
Jazyk:	angličtina
Zdroj:	Science immunology [Sci Immunol] 2019 Nov 15; Vol. 4 (41).
DOI:	10.1126/sciimmunol.aav2026
Abstrakt:	Influenza A virus (IAV) infection-associated morbidity and mortality are a key global health care concern, necessitating the identification of new therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of γδ T cells in the lung that improved barrier functions, thereby enhancing antiviral resistance. Expansion of these protective γδ T cells required metabolic adaptation to a ketogenic diet because neither feeding mice a high-fat, high-carbohydrate diet nor providing chemical ketone body substrate that bypasses hepatic ketogenesis protected against infection. Therefore, KD-mediated immune-metabolic integration represents a viable avenue toward preventing or alleviating influenza disease. (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze:	MEDLINE
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