Validation of the COPD Assessment Test (CAT) as an Outcome Measure in Bronchiectasis.
| Autor: | Finch S; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland., Laska IF; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland., Abo-Leyah H; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland., Fardon TC; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland., Chalmers JD; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland. Electronic address: jchalmers@dundee.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | Chest [Chest] 2020 Apr; Vol. 157 (4), pp. 815-823. Date of Electronic Publication: 2019 Nov 12. |
| DOI: | 10.1016/j.chest.2019.10.030 |
| Abstrakt: | Background: Objective assessment of symptoms in bronchiectasis is important for research and in clinical practice. The COPD Assessment Test (CAT) is a short, simple assessment tool widely used in COPD. The items included in the CAT are not specific to COPD and also reflect the dominant symptoms of bronchiectasis. We therefore performed a study to validate the CAT as an outcome measure in bronchiectasis. Methods: The CAT was administered to two cohorts of bronchiectasis patients along with other quality of life questionnaires. Patients underwent comprehensive clinical assessment. One cohort had repeated questionnaires collected before-and-after treatment of acute exacerbations. We analyzed convergent validity, repeatability, and responsiveness of the score and calculated the minimum clinically important difference (MCID) using a combination of distribution and anchor-based methods. Results: In both cohorts there were positive correlations between the CAT and the St. George's Respiratory Questionnaire (r = 0.90, P < .0001 and r = 0.87, P < .0001). There was an inverse relationship between CAT and Quality of Life - Bronchiectasis Respiratory Symptoms Scale (r = -0.75, P < .0001) and Leicester Cough Questionnaire score (r = -0.77, P < .0001). Patients with more severe disease, based on the bronchiectasis severity index, had significantly higher CAT scores. CAT also correlated with FEV Conclusions: CAT is a valid, responsive symptom assessment tool in bronchiectasis. The MCID is estimated as 4 points. (Copyright © 2019 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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