The TP53 p.R337H mutation is uncommon in a Brazilian cohort of pediatric patients diagnosed with ependymoma.

Autor: de Almeida Magalhães T; Departments of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Borges KS; Departments of Pediatrics, Ribeirão Preto Medical School, University of São Paulo - USP, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil. ksborges@usp.br., de Sousa GR; Departments of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Brandalise SR; Molecular Biology Laboratory, Boldrini Children's Center, Campinas, SP, Brazil.; Medical Genetics Department, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil., Seidinger AL; Molecular Biology Laboratory, Boldrini Children's Center, Campinas, SP, Brazil.; Medical Genetics Department, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil., Scrideli CA; Departments of Pediatrics, Ribeirão Preto Medical School, University of São Paulo - USP, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil., Oba-Shinjo SM; Laboratory of Cellular and Molecular Biology, Department of Neurology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Yunes JA; Molecular Biology Laboratory, Boldrini Children's Center, Campinas, SP, Brazil.; Medical Genetics Department, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil., Tone LG; Departments of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.; Departments of Pediatrics, Ribeirão Preto Medical School, University of São Paulo - USP, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2020 Mar; Vol. 41 (3), pp. 691-694. Date of Electronic Publication: 2019 Nov 14.
DOI: 10.1007/s10072-019-04112-x
Abstrakt: Background: Ependymoma (EPN) is the third most common childhood cancer of the central nervous system. RELA fusion-positive EPN accounts for approximately 70% of all childhood supratentorial tumors and shows the worst prognosis among the supratentorial EPNs. TP53 mutation is infrequent in RELA fusions EPNs. In the population from the Southern region of Brazil, there is a high incidence of the germline TP53 p.R337H mutation that predisposes carriers to develop early-onset tumors. However, despite this high incidence, the frequency of this mutation among EPN patients remains to be determined. Here, we investigated the presence of the TP53 p.R337H mutation in a larger cohort of pediatric EPNs of three institutions located in the state of São Paulo, Brazil.
Methods: The TP53 p.R337H mutation was screened by conventional RT-PCR and Sanger sequencing in 49 pediatric EPNs diagnosed during the period from 1995 to 2016.
Results: We described for the first time a case of a 5-year-old girl with RELA fusion EPN with a heterozygous TP53 p.R337H mutation.
Conclusions: The present finding indicates that the TP53 p.R337H germline mutation is uncommon in patients with EPN in Brazil and screening of pediatric patients RELA fusion EPN may be informative to better understand the role of TP53 germline mutations in the development and prognosis of these tumors.
Databáze: MEDLINE
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