Clinical Features, Treatment, Prognosis, and Mortality in Paraquat Poisonings: A Hospital-Based Study in Iran.

Autor:	Oghabian Z; Department of Clinical Toxicology, Gastroenterology and Hepatology Research Center, Kerman University of Medical Science, Kerman, Iran., Williams J; Department of Paraclinical Sciences, University of Pretoria, Pretoria, South Africa., Mohajeri M; Department of Medical Biotechnology, Mashhad University of Medical Science, Mashhad, Iran., Nakhaee S; Department of Toxicology, Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran., Shojaeepour S; Department of Pathology, Pathology and Stem Cell Research Center, Birjand University of Medical Sciences, Birjand, Iran., Amirabadizadeh A; Department of Toxicology, Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran., Elhamirad S; Department of infectious disease, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran., Hajihosseini M; School of Public Health, University of Alberta, Edmonton, AB, Canada., Mansouri B; Department of toxicology, Substance Abuse Prevention Research, Health Institute, Birjand University of Medical Sciences, Birjand, Iran., Mehrpour O; Department of Toxicology, Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Jazyk:	angličtina
Zdroj:	Journal of research in pharmacy practice [J Res Pharm Pract] 2019 Oct 16; Vol. 8 (3), pp. 129-136. Date of Electronic Publication: 2019 Oct 16 (Print Publication: 2019).
DOI:	10.4103/jrpp.JRPP_18_71
Abstrakt:	Objective: The aim of the present study was to evaluate the demographics, clinical characteristics, fatal dose, the efficacy of treatments, and prognosis in paraquat (PQ) poisoning in the Kerman Province of Iran. Methods: This analytical cross-sectional study was conducted on 126 PQ poisoned patients who were referred to Afzalipour Hospital during 2006-2015. Demographic variables such as age and gender, signs and symptoms of poisoning, the estimated ingested dosage of PQ, and clinical outcome were extracted from medical records. Patients were compared and categorized into two groups considering the outcome: survivors and nonsurvivors. Patients with nonoral exposures, combined drug exposures, PQ exposures more than 24 h before the presentation, and critical underlying diseases were not included in the study. Findings: Our results indicated that the mean dose of PQ used by all patients was 2358 mg, which was reported as 1846 and 2812 mg in females and males, respectively. Moreover, the results showed that the highest mortality rate was in patients with respiratory distress, followed by oral ulceration and excess salivation. In all PQ-poisoned patients, the dose of greater than approximately 2250 mg predicted death with 86.2% specificity and 75.7% sensitivity. Conclusion: Based on the results of the present study, the mortality rate in PQ-poisoned patients depended on the dose of poison, blood sugar level, and aspartate transaminase levels. Our results suggest that these parameters have excellent prognostic value for the prediction of mortality. Competing Interests: There are no conflicts of interest. (Copyright: © 2019 Journal of Research in Pharmacy Practice.)
Databáze:	MEDLINE
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